2015 |
Miller, Duncan Lee Development of Resource-Constrained Sensors and Actuators for In-Space Satellite Docking and Servicing PhD Thesis 2015, ISSN: 1098-6596. Abstract | BibTeX | Tags: icle, ★ @phdthesis{millerDevelopmentResourceConstrainedSensors2015, title = {Development of Resource-Constrained Sensors and Actuators for In-Space Satellite Docking and Servicing}, author = {Duncan Lee Miller}, issn = {1098-6596}, year = {2015}, date = {2015-01-01}, number = {June}, abstract = {applicability for this approach.}, keywords = {icle, ★}, pubstate = {published}, tppubtype = {phdthesis} } applicability for this approach. |
2012 |
Lee, Sunghak Statistical Risk Estimation for Communication System Design PhD Thesis 2012, ISSN: 1098-6596. Abstract | Links | BibTeX | Tags: Axial crushing, Energy absorption, icle, Impact absorption energy, Origami pattern, Space frame, Thin-walled tubes, Triggering dent @phdthesis{leeStatisticalRiskEstimation2012, title = {Statistical Risk Estimation for Communication System Design}, author = {Sunghak Lee}, doi = {10.1017/CBO9781107415324.004}, issn = {1098-6596}, year = {2012}, date = {2012-01-01}, volume = {53}, number = {9}, abstract = {Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach.}, keywords = {Axial crushing, Energy absorption, icle, Impact absorption energy, Origami pattern, Space frame, Thin-walled tubes, Triggering dent}, pubstate = {published}, tppubtype = {phdthesis} } Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. |
2011 |
Courtney, Daniel 2011, ISSN: 1098-6596. Abstract | Links | BibTeX | Tags: icle @phdthesis{courtneyIonicLiquidIon2011, title = {Ionic Liquid Ion Source Emitter Arrays Fabricated on Bulk Porous Substrates for Spacecraft Propulsion}, author = {Daniel Courtney}, doi = {10.1017/CBO9781107415324.004}, issn = {1098-6596}, year = {2011}, date = {2011-01-01}, volume = {1}, number = {June}, abstract = {onic Liquid Ion Sources (ILIS) are a subset of electrospray capable of producing bipolar beams of pure ions from ionic liquids. Ionic liquids are room temperature molten salts, characterized by negligible vapor pressures, relative high conductivities and surface ten- sions lower than water. Compared with the colloid form of electrospray, renowned for its applications to spectroscopy, ILIS yield highly monoenergetic beams composed entirely of ions. In this respect they are similar to Liquid Metal Ions Sources, but o er the ability to emit both positive and negative ions from a benign propellant that remains in the liquid state over a wide range of temperatures. When applied to spacecraft propulsion these sources are very power e cient and yield high speci c impulses. Furthermore, the low ow rates and negligible vapor pressures of ionic liquids allow for passive feeding systems which can remain exposed to the vacuum of space. This con guration would remove the need for pressurized propellant tanks or valves, both of which are di cult to miniaturize for small satellites. However; the thrust produced from each emitter is very low, less than 0.1 N . As a result, compact arrays of active ILIS have been sought since their discovery. If arrays of modest packing density ( 5 emitters/mm 2 ) could be achieved, ILIS as thrusters would o er a scalable form of propulsion capable of providing useful thrust levels to small satellites with performance comparable to established, but di cult to miniaturize, plasma based ion engines. This research has sought a technique for creating arrays of ILIS from bulk porous sub- strates as part of an overall process for microfabricating complete thrusters. The thesis includes a survey of potential fabrication methods considering both suitability for form- ing arrays of ILIS and the ability to integrate each technique within a thruster packaging process. Electrochemical etching is highly selective and can proceed at rates which are limited by mass transport conditions. In this thesis we show how this etching regime can be exploited to smoothly remove material from the surface of a bulk porous metal substrate without damaging the internal pore structure. Dry lm photoresists have been identi ed as a suitable alternative to spin on techniques for porous materials and have been applied within an electrochemical etching process. A two step process for forming arrays of ILIS has been motivated using numerical sim- ulations of the etching process to predict emitter pro les and investigate the impacts of non-uniform etching conditions. These concepts have been applied experimentally using a custom built, automated, etching station capable of repeatedly producing arrays of 480 emit- ters spaced 500 m apart on a 1 x 1 cm porous nickel substrate pre-mounted, and aligned, 3 within a silicon thruster package. The emitters are typically 165 m tall with rounded tips suitable for operation as ILIS. Pulsed voltage conditions were found to signi cantly enhance wafer level uniformity enabling fabrication of functional emitters within a few hundred m of the substrate boundary. The structures have been smoothed and rounded, making them suitable for use as ILIS, during a secondary etch process using electrolytes doped with nickel chloride to suppress transient e ects. These doped solutions enabled a few m of material to be removed selectively from the porous surface while maintaining smooth features. These arrays have been mounted and aligned with electrostatic grids to demonstrate their emission capabilities. Propellant has been fed to the emitters by capillarity within the porous bulk and then extracted at potentials as low as 850 V . Beam currents exceeding several 100 A at both positive and negative polarities have been measured using both EMI- Im and EMI-BF 4 ionic liquid propellant. Two complete devices were tested yielding large beam currents and very high transmission fractions ( 88-100 %) from both attempts. We estimate that these devices can supply 10's of N of thrust at modest operating potentials, 1.5 kV , with a speci c impulse of roughly 2000-3000 s . When completely packaged, the thrusters measure 1.2 x 1.2 x 0.2 cm , weigh less than 1 g and require less than 0.65 W of operating power. These characteristics would be ideal for a small satellites where volume, mass and power are all at a premium, while the thrust levels would be su cient to enable a variety of orbit variation and attitude control maneuvers. For example, applied to a CubeSat, this type of thruster system, including PPU, would occupy roughly 10 % of the spacecraft volume and mass while enabling de-orbiting from an 800 km altitude in roughly 100 days, compared with many years when left to decay naturally.}, keywords = {icle}, pubstate = {published}, tppubtype = {phdthesis} } onic Liquid Ion Sources (ILIS) are a subset of electrospray capable of producing bipolar beams of pure ions from ionic liquids. Ionic liquids are room temperature molten salts, characterized by negligible vapor pressures, relative high conductivities and surface ten- sions lower than water. Compared with the colloid form of electrospray, renowned for its applications to spectroscopy, ILIS yield highly monoenergetic beams composed entirely of ions. In this respect they are similar to Liquid Metal Ions Sources, but o er the ability to emit both positive and negative ions from a benign propellant that remains in the liquid state over a wide range of temperatures. When applied to spacecraft propulsion these sources are very power e cient and yield high speci c impulses. Furthermore, the low ow rates and negligible vapor pressures of ionic liquids allow for passive feeding systems which can remain exposed to the vacuum of space. This con guration would remove the need for pressurized propellant tanks or valves, both of which are di cult to miniaturize for small satellites. However; the thrust produced from each emitter is very low, less than 0.1 N . As a result, compact arrays of active ILIS have been sought since their discovery. If arrays of modest packing density ( 5 emitters/mm 2 ) could be achieved, ILIS as thrusters would o er a scalable form of propulsion capable of providing useful thrust levels to small satellites with performance comparable to established, but di cult to miniaturize, plasma based ion engines. This research has sought a technique for creating arrays of ILIS from bulk porous sub- strates as part of an overall process for microfabricating complete thrusters. The thesis includes a survey of potential fabrication methods considering both suitability for form- ing arrays of ILIS and the ability to integrate each technique within a thruster packaging process. Electrochemical etching is highly selective and can proceed at rates which are limited by mass transport conditions. In this thesis we show how this etching regime can be exploited to smoothly remove material from the surface of a bulk porous metal substrate without damaging the internal pore structure. Dry lm photoresists have been identi ed as a suitable alternative to spin on techniques for porous materials and have been applied within an electrochemical etching process. A two step process for forming arrays of ILIS has been motivated using numerical sim- ulations of the etching process to predict emitter pro les and investigate the impacts of non-uniform etching conditions. These concepts have been applied experimentally using a custom built, automated, etching station capable of repeatedly producing arrays of 480 emit- ters spaced 500 m apart on a 1 x 1 cm porous nickel substrate pre-mounted, and aligned, 3 within a silicon thruster package. The emitters are typically 165 m tall with rounded tips suitable for operation as ILIS. Pulsed voltage conditions were found to signi cantly enhance wafer level uniformity enabling fabrication of functional emitters within a few hundred m of the substrate boundary. The structures have been smoothed and rounded, making them suitable for use as ILIS, during a secondary etch process using electrolytes doped with nickel chloride to suppress transient e ects. These doped solutions enabled a few m of material to be removed selectively from the porous surface while maintaining smooth features. These arrays have been mounted and aligned with electrostatic grids to demonstrate their emission capabilities. Propellant has been fed to the emitters by capillarity within the porous bulk and then extracted at potentials as low as 850 V . Beam currents exceeding several 100 A at both positive and negative polarities have been measured using both EMI- Im and EMI-BF 4 ionic liquid propellant. Two complete devices were tested yielding large beam currents and very high transmission fractions ( 88-100 %) from both attempts. We estimate that these devices can supply 10's of N of thrust at modest operating potentials, 1.5 kV , with a speci c impulse of roughly 2000-3000 s . When completely packaged, the thrusters measure 1.2 x 1.2 x 0.2 cm , weigh less than 1 g and require less than 0.65 W of operating power. These characteristics would be ideal for a small satellites where volume, mass and power are all at a premium, while the thrust levels would be su cient to enable a variety of orbit variation and attitude control maneuvers. For example, applied to a CubeSat, this type of thruster system, including PPU, would occupy roughly 10 % of the spacecraft volume and mass while enabling de-orbiting from an 800 km altitude in roughly 100 days, compared with many years when left to decay naturally. |
2008 |
Odegard, Ryan 2008, ISSN: 1098-6596. Abstract | Links | BibTeX | Tags: icle @phdthesis{odegardIncreasedConfidenceConcept2008, title = {Increased Confidence in Concept Design through Trade Space Exploration and Multiobjective Optimization}, author = {Ryan Odegard}, doi = {10.1017/CBO9781107415324.004}, issn = {1098-6596}, year = {2008}, date = {2008-01-01}, volume = {53}, number = {9}, abstract = {Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach.}, keywords = {icle}, pubstate = {published}, tppubtype = {phdthesis} } Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. |
2007 |
Sakaguchi, Aya Micro-Electromagnetic Formation Flight of Satellite Systems PhD Thesis 2007, ISSN: 1098-6596. Abstract | Links | BibTeX | Tags: icle @phdthesis{sakaguchiMicroElectromagneticFormationFlight2007, title = {Micro-Electromagnetic Formation Flight of Satellite Systems}, author = {Aya Sakaguchi}, doi = {10.1017/CBO9781107415324.004}, issn = {1098-6596}, year = {2007}, date = {2007-01-01}, abstract = {Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach.}, keywords = {icle}, pubstate = {published}, tppubtype = {phdthesis} } Predicting the binding mode of flexible polypeptides to proteins is an important task that falls outside the domain of applicability of most small molecule and protein-protein docking tools. Here, we test the small molecule flexible ligand docking program Glide on a set of 19 non-$alpha$-helical peptides and systematically improve pose prediction accuracy by enhancing Glide sampling for flexible polypeptides. In addition, scoring of the poses was improved by post-processing with physics-based implicit solvent MM- GBSA calculations. Using the best RMSD among the top 10 scoring poses as a metric, the success rate (RMSD $łeq$ 2.0 AA for the interface backbone atoms) increased from 21% with default Glide SP settings to 58% with the enhanced peptide sampling and scoring protocol in the case of redocking to the native protein structure. This approaches the accuracy of the recently developed Rosetta FlexPepDock method (63% success for these 19 peptides) while being over 100 times faster. Cross-docking was performed for a subset of cases where an unbound receptor structure was available, and in that case, 40% of peptides were docked successfully. We analyze the results and find that the optimized polypeptide protocol is most accurate for extended peptides of limited size and number of formal charges, defining a domain of applicability for this approach. |
2005 |
Kwon, Daniel W Electromagnetic Formation Flight of Satellite Arrays PhD Thesis 2005, ISSN: 15710297. Abstract | Links | BibTeX | Tags: 1700, 250-721-8542, adulteration, b, books are developed from symposia sponsored by, c, ca, canada, Capsules, Cascade theory, causality, chemical composition, Chemistry, cointegration, comprehensive books developed, correspondence to, Cultivation, Delayed-Action Preparations, department of economics, Diffusion, dimension, economic growth, Electron, email, from ACS sponsored, functional properties, Gel point, Gelatin, Gelation mechanisms, giles, icle, jgiles, judith a, main products, medicinal uses, Microchemistry, Microchemistry: methods, Microscopy, misspecification, model, Nigella, ot, Percolation theory, Permeability, Physical, Physicochemical Phenomena, po box, Polymers, quality specifications, robustness, Rubber elasticity, Scanning, Sol-gel and gel-sol transitions, Starch gels, telephone, The ACS Symposium Series was first published in 1, The ACS Symposium Series was first published in 19, time series models, toxicity, university of victoria, uvic, v8w 2y2, victoria, we are grateful, Whey protein nanofibril gels @phdthesis{kwonElectromagneticFormationFlight2005a, title = {Electromagnetic Formation Flight of Satellite Arrays}, author = {Daniel W Kwon}, doi = {10.1007/978-1-4614-7990-1}, issn = {15710297}, year = {2005}, date = {2005-01-01}, volume = {12 Suppl 1}, number = {9}, abstract = {This book is an attempt to introduce the enormous amount of literature on solidification heat transfer. Many of the applications have been directed to water/ice soil systems.}, keywords = {1700, 250-721-8542, adulteration, b, books are developed from symposia sponsored by, c, ca, canada, Capsules, Cascade theory, causality, chemical composition, Chemistry, cointegration, comprehensive books developed, correspondence to, Cultivation, Delayed-Action Preparations, department of economics, Diffusion, dimension, economic growth, Electron, email, from ACS sponsored, functional properties, Gel point, Gelatin, Gelation mechanisms, giles, icle, jgiles, judith a, main products, medicinal uses, Microchemistry, Microchemistry: methods, Microscopy, misspecification, model, Nigella, ot, Percolation theory, Permeability, Physical, Physicochemical Phenomena, po box, Polymers, quality specifications, robustness, Rubber elasticity, Scanning, Sol-gel and gel-sol transitions, Starch gels, telephone, The ACS Symposium Series was first published in 1, The ACS Symposium Series was first published in 19, time series models, toxicity, university of victoria, uvic, v8w 2y2, victoria, we are grateful, Whey protein nanofibril gels}, pubstate = {published}, tppubtype = {phdthesis} } This book is an attempt to introduce the enormous amount of literature on solidification heat transfer. Many of the applications have been directed to water/ice soil systems. |